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Vitamin

Folate (5-MTHF)

L-5-MTHF

Dose range

100µg200µg
Bypasses MTHFR conversion step
Immediately bioavailable
Optimal for ~40% of population
Vegan & gluten-free
Folate (5-MTHF)

What is Folate (5-MTHF)?

The bioavailable, methylated form of folate — bypasses the MTHFR enzyme step that affects up to 40% of the population. Contributes to normal psychological function, normal blood formation and has a role in the process of cell division.

Why L-5-MTHF?

Calcium L-5-methyltetrahydrofolate is the naturally active form of folate that bypasses the MTHFR enzyme — the conversion step that is genetically impaired in approximately 40% of the population — ensuring direct cellular availability regardless of genetic variation.

What are the benefits of Folate (5-MTHF)?

MTHFR-bypass bioavailability

Unlike folic acid, 5-MTHF does not require the MTHFR enzyme for activation. For the substantial proportion of people with reduced MTHFR activity, this is the only form of folate that reliably reaches tissues in active form.

Methylation & mood

5-MTHF is the methyl donor in pathways supporting normal neurotransmitter function. Adequate methylfolate status contributes to normal psychological function and mood.

DNA integrity & cell health

As the active cellular form of folate, 5-MTHF directly participates in DNA synthesis, repair and methylation — supporting genomic stability and the integrity of rapidly dividing cells.

Supports

homocysteinepsychological functioncell division

Tap any underlined tag to see the full authorised health claim wording. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Common questions about Folate (5-MTHF)

Folate (5-MTHF) is one of 31 compounds your formula can draw from.

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